Many initiatives have been conducted at the global and country-level to enhance the use of research evidence in health policymaking.1 However, evidence-informed health policymaking (EIHP) is still far from the norm, particularly in many low- and middle-income countries (LMICs), calling for further efforts to address challenges of EIHP.2 The Islamic Republic of Iran has initiated some measures toward promoting EIHP, including considering the financial burden of an issue in agenda setting, sensitivity analysis of policy options based on their feasibility, and prioritizing policy options according to multi-criteria decision-making models.3 Nevertheless, using evidence in decision-and policymaking has not been fully institutionalized. Hence, it is required to identify the main constraints/challenges of EIHP and define context-sensitive strategies to address them purposively.